Description
No-Spa Forte Tablet, manufactured by Sanofi Aventis, contains 80 mg of drotaverine hydrochloride per tablet. It is primarily used as an antispasmodic agent to relieve smooth muscle spasms in various parts of the body.
Uses
No-Spa Forte is indicated for:
- Biliary tract diseases: Effective for treating conditions like biliary colic, cholecystitis, and cholelithiasis.
- Urinary tract diseases: Can be used for ureteral colic, renal colic, and dysuria.
- Gastrointestinal tract diseases: Helpful in treating conditions like irritable bowel syndrome, biliary dyskinesia, and esophageal spasm.
- Dysmenorrhea: Provides relief from painful menstruation.
Mechanism of Action
Drotaverine, the active ingredient in No-Spa Forte, is a selective inhibitor of phosphodiesterase IV (PDE IV). By inhibiting PDE IV, it increases cAMP levels, leading to smooth muscle relaxation through inactivation of myosin light chain kinase (MLCK).
Dosage
The recommended dosage for adults is typically:
- 40 mg (1/2 tablet) to 80 mg (1 tablet) taken 2-3 times daily.
- The maximum daily dose should not exceed 240 mg (3 tablets).
For children over 12 years old, the usual dose is 20-40 mg (1/4 to 1/2 tablet) taken 1-2 times daily.
Side Effects
Common side effects may include:
- Constipation
- Dry mouth
- Dizziness
- Headache
- Nausea
Precautions
- No-Spa Forte should be used with caution in patients with cardiac disorders, hypertension, or glaucoma.
- It is contraindicated in patients with myasthenia gravis, paralytic ileus, or prostatic hypertrophy.
- Pregnant women and nursing mothers should consult a healthcare provider before using this medication.
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